Wednesday, May 8, 2013

Phantom Pain, It's Real!

Note: Phantom pain is real, most amputees feel it's effects in some form. For some it's a minor irritation, for others it's as painful as the amputation itself. Searching the Internet, I found tons of information about phantom pain and many ways in which to relieve it.

There is a difference between 'phantom sensations' and 'phantom pain'. Phantom sensations can feel like an itch you can't scratch, or the feeling that you can wiggle your toes. Caution should be used at this time as you could accidently take a step thinking your leg is still there. Phantom pain is the opposite. It is an extremely painful experience. It can begin like a cramp and steadily increase in intensity. Or it can hit you without any warning. This has happened to me many times. For some, putting ice on your stump will relieve the pain, walking, moving about will also help eliminate some of it. If the pain is too much to deal with, immediately consult your physician. There are medications to help deal with this painful process.

~LadyAmp

U. C. San Diego Neurobiologist at Forefront of Phantom Research

Richard Mooney, Mutual Amputee Aid Foundation, with V S. Ramachandran, M.D., Ph.D., University of California, San Diego
with permission 3/2000

Compared to some medical conditions, phantom limb sensation is a relatively modern phenomenon. This is because amputation was not widely practiced - at least not successfully - until the Civil War. However, almost every amputee has experienced the phenomenon - many quite vividly.

The first known reference to phantom sensation (and related pain) didn't appear in a medical journal but in the Atlantic Monthly in 1866, when the story of civil War veteran, George Dedlow, appeared. Since then, spurred on by their patients' pain that often accompanies the phantoms and the urgent need to find effective treatments for it, physicians and researchers have developed and tested many different theories about where phantoms originate and why. Although scientific research has solved many other perplexing medical puzzles during the last 100 years, phantoms still remain a relative mystery.

It was originally thought that phantoms and the pain which is often associated with them originated in the stump, perhaps as a result of neuromas that tend to form at the ends of severed nerves. If that were true, however, there would be no explanation for the fact that many congenital amputees - people who neither had severed nerves nor had they ever experienced having real arms or legs - frequently experience phantom sensations. Neither would it explain phantom vision experienced by many people who suffer vision loss due to cataracts or retina degeneration, or phantom hearing experienced by many people who lose their "real" hearing.

The only sensible explanation is that phantoms occur, not in the limbs, but in the brain. If that is the case, then much of the pain must also originate in the brain. (I should emphasize that phantom pain is a physiological, not psychological phenomenon. Clearly, phantom pain is not imaginary!)

In the "normal," four-limbed body, sensations experienced by the "receptor" nerves in the hands, arms, feet, and legs are sent to the spinalcord over a network of "transmission" nerves. The spinal cord is kind of a "neural superhighway" up which all these signals travel to the brain. The signals are received deep within the brain by the thalamus, a kind of "relay station" that routes the signals through its specialized circuits that are assigned to handle signals from each part of the body. The thalamus then reintegrates the signals and sends them on to the somatosensory cortex - the part of the brain that converts them to sensations we interpret as hot, cold, rough, smooth, etc.

Research done in the 1960s suggested that the brain was "hard wired," that is, its internal connections were fixed in place, something like the electrical wiring in a house. If that were the case, then when a limb is amputated, no signal from it would reach the brain and that would be that - something like having the person on the other end of a phone conversation hang up.

"But that isn't what happens, " Dr. Ramachandran asserts. "My research, and that of my colleagues at U.C. San Francisco, Vanderbilt University, and elsewhere, has revealed that the brain somehow 're- wires' itself so that when the 'wires are cut' between a thumb, for example, and the part of the brain that listens for thumb signals, that part of the brain doesn't just sit there listening to a 'dead line' as it would if the brain were hard wired. Instead, as happens with many amputees, those brain parts rewire to next-door brain parts, which in the human body, happen to be those that listen for face signals. Thus, if I touch a certain part of a patient's face with a Q-Tip, he is very likely to feel his phantom thumb!

"A lot of my work with arm amputees involves charting those 'face maps' in detail. Once I can connect specific areas of the face with specific areas of the absent hand, I can then create 'brain maps' using a technique known as 'Functional Magnetic Resonance Imaging.' Through this process, we are learning many new things about how the human brain works. This should eventually provide valuable insight into how people recover from brain injuries, how we learn, and of course, how phantom pain occurs and how to treat it effectively.

"So far, we've learned a little about phantom pain. I suspect the motor command centers of the brain may be one of the causes of it. For example, the motor command center may send signals to a missing hand, telling it to move. In absence of feedback telling the brain that the hand has done what was commanded, the brain may literally flood the neural pathwayswith more 'move' signals - much more and more forcefully than normal. The brain may perceive this 'flood' as pain.

"Certainly, much more needs to be learned before we can explain phantom pain with certainty. The exciting part of my research for amputees is that if the phantoms are in the brain, then the answer to the pain may be there too."

Professor Ramachandran is the head of the Brain and Perception Laboratory in the Department of Psychology at the University of California at San Diego.

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